According to the Syrian Interior Ministry, explosives detonated on a busy street in rural Damascus.
A local resident heard the blast around 5:30 p.m. local time.
Security forces cordoned off the area immediately.
The interior ministry said several agencies responded to the blast, including the Syrian criminal police.
Authorities previously said the bomb was hidden in a taxi, Al Jazeera reported.
However, they later reported that the explosives were on a motorcycle that detonated next to the taxi.
Another local resident said the blast happened near a security building a few meters from the Sayeda Zeinab Mausoleum, the tomb of the Prophet Mohammed's grandson.
“We heard a big bang and people started running,” the local resident told AFP.
“Then the ambulance came and the security forces cordoned off the area,” he continued.
A major pilgrimage site for Shia Muslims, the mosque on the southern outskirts of Damascus was the target of another bomb attack earlier this week, injuring two people.
No militant group has claimed responsibility for this week's bombings.
Photos shared by state-run Al-Ikhbariya TV, a pro-government broadcaster, showed a charred taxi.
In a video shared on social media, people carry two men covered in blood and dust off the ground and call for help.
The glass fronts of neighboring shops were shattered, and one of them caught fire.
This area is a holy place for Shia Muslims.
The blast was the second in the Sayeda Zeinab neighborhood in the days leading up to Ashura, ABC News reported.
On Tuesday (25/07/2023) Syrian state media quoted a police officer as saying that two civilians were injured when a motorcycle filled with explosives exploded.