US Secret Service officials found suspicious powder during a routine check in an area accessible to White House tour groups.
Meanwhile, the Washington Post quoted US Secret Service spokesman Anthony Guglielmi as saying the Washington DC Fire Department had been contacted to assess the powder found.
He said firefighters responding to the call late Sunday could hear a recording of a radio message saying the suspect powder had tested positive for cocaine at the White House.
The message, Guglielmi said, was posted by the website OpenMHz, a radio that records and archives calls from police, fire or ambulance services.
When the cocaine was found, US President Joe Biden and his family were at Camp David, Maryland.
Joe Biden and his family just returned to the White House on Tuesday (4/7/2023 local time) to attend a National Education Association event to commemorate America's independence.
A senior police official announced the discovery of cocaine in a cell phone storage room frequently used by White House staff and guests.
Following the cocaine find, the White House complex was closed around 8:45 p.m. local time on Sunday.
Preliminary tests confirmed the suspect powder was cocaine.
The US secret service will investigate how the found cocaine got into the White House.
They said all surveillance cameras and logs were used to find out who had access to the area where the cocaine was found.
For information, cocaine is a prohibited drug listed on Schedule II of the US Drug Act, meaning it has a high potential for abuse.
While the West Wing is part of the White House, it houses the US President's offices, including the Oval Office and the Situation Room.
Also located in this area are the offices of the vice president, the White House chief of staff, the press secretary, and hundreds of other employees who are permitted entry.